This article takes an in-depth look at berberine, how it works, and how it can affect your health.
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It may also be linked to other benefits and could aid in the treatment of conditions such as depression and nonalcoholic fatty liver disease (NAFLD).
In particular, berberine has been shown to lower blood sugar, increase weight loss, and improve heart health.
Berberine is a supplement that has been associated with several potential health benefits.
Berberine is a compound found naturally in many plants. Some research suggests that it may help promote weight loss, enhance blood sugar regulation, and protect against several chronic conditions.
Berberine is a compound that can be extracted from several plants. It has a long history of use in traditional Chinese medicine.
Now, modern science suggests that it has impressive benefits for many health concerns ( 2 ).
Berberine has a long history in traditional Chinese medicine, where it has been used to treat various ailments ( 1 ).
Technically, it belongs to a class of compounds called alkaloids. It's yellow and is often used as a dye.
Berberine is a bioactive compound that can be extracted from several plants, including a group of shrubs called Berberis ( 1 ).
Berberine has a variety of functions inside cells. One of the main functions is activating an important enzyme called AMPK, which regulates metabolism.
Berberine also affects other molecules inside cells and may even affect which genes are turned on or off. This could help protect against many chronic health conditions ( 7 ).
AMPK plays a key role in regulating metabolism and energy levels and is found in cells throughout your body ( 5 , 6 ).
One of the main actions of berberine is to activate an enzyme inside cells called AMP-activated protein kinase (AMPK), according to some animal studies ( 3 , 4 ).
Berberine has been tested in hundreds of studies.
Berberine has been shown to help lower blood sugar and HbA1c. It may be as effective as some diabetes medications.
It works very well in combination with lifestyle changes and has additive effects when used with other blood sugar-lowering drugs ( 13 ).
According to an older review of 14 studies, berberine may be as effective as certain oral diabetes drugs, including metformin, glipizide, and rosiglitazone ( 12 ).
It also lowered hemoglobin A1c (HbA1c), a marker of long-term blood sugar regulation, by 12% and improved levels of blood lipids such as cholesterol and triglycerides ( 11 ).
In a study of 116 people with diabetes, taking 1 gram of berberine per day lowered fasting blood sugar by 20% ( 11 ).
It seems to work via multiple mechanisms and may help ( 9 , 10 ):
Many studies show that berberine can significantly lower blood sugar levels in people with type 2 diabetes ( 8 ).
Some studies suggest that berberine can contribute to significant weight loss while improving many other health markers.
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However, more research is needed on the potential weight loss effects of berberine.
Berberine also appears to inhibit the growth of fat cells at the molecular level, which could help promote weight loss ( 16 ).
Additionally, a review of 12 studies found that supplementing with berberine led to significant reductions in body weight, body mass index, and belly fat . It also decreased levels of C-reactive protein, a marker of inflammation ( 15 ).
In one older 12-week study in people with obesity, taking 500 milligrams (mg) of berberine three times per day caused about 5 pounds of weight loss, on average. The participants also lost 3.6% of their body fat ( 14 ).
Berberine may also be effective as a weight loss supplement .
Heart disease is currently the leading cause of death around the globe (17).
Many factors that can be measured in your blood are associated with an increased risk of heart disease.
As it turns out, berberine has been shown to improve many of these factors.
According to a review of 16 studies, it could help (18):
It has also been shown to lower apolipoprotein B by 13'15% in some older studies, which is an important risk factor for heart disease (19, 20).
According to some research, berberine works by inhibiting an enzyme called PCSK9. This leads to more LDL cholesterol being removed from your bloodstream (21).
Diabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, and this supplement seems to help improve all of these conditions (7).
Given the beneficial effects on all these risk factors, it seems likely that berberine could reduce the risk of heart disease, though more research is needed.
SummaryStudies suggest that berberine reduces cholesterol and triglyceride levels while raising HDL (good) cholesterol levels. While more research is needed, it may lower the risk of heart disease in the long term.
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