Product Description
For more information, please visit Lidocaine HCl cas 73-78-9.
Lidocaine works as a local anesthetic by reversibly closing sodium channels and blocking action potential transmission across nerve fibers. Sensory nerve fibers are blocked earlier than motor nerve fibers, so low doses of lidocaine can exert selective sensory block. Lidocaine can also inhibit Chemicalbook arrhythmia, which belongs to class B antiarrhythmic drugs. It can reduce ventricular rate, shorten action potential time and absolute refractory period, and prolong relative refractory period. Lidocaine acts quickly and for a short time. Adding epineph rine to lidocaine can reduce systemic absorption rate and thus prolong anesthesia time.
Synonym
2-(Diethylamino)-2',6'-acetoxylidide;2-(diethylamino)-2',6'-acetoxylidide;2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid;2',6'-AcetoChemicalbookxylidide,2-(diethylamino)-;6'-acetoxylidide,2-(diethylamino)-2;Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-;Ligoncaine;Maricaine.
Specification
Product name
Lidocaine
Specification
99%
Appearance
white powder
Test Method
HPLC
Shelf Life
2 years
Function & Application
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Function
Lidocaine is indicated for acute ventricular arrhythmias caused by acute myocardial infarction, surgery, digitalis poisoning, and cardiac catheters, including premature ventricular beats, ventricular tachycardia, and ventricular fibrillation. Secondly, it is also used for epileptic persistence.
Application
Lidocaine is a first-line agent for the treatment of ventricular arrhythmias caused by acute and severe hemodynamic abnormalities. It is also effective for some supraventricular arrhythmias, such as bypass-mediated supraventricular tachycardia and cardioversion of acute or parasympathetic atrial fibrillation. It is widely used for mucosal surface anesthesia (e.g., before endotracheal intubation). EMLA cream is used for skin surface anesthesia before intravenous intubation. To ensure the anesthetic effect, it should be applied to the skin for 45 to 60 minutes and wrapped with an airtight dressing to promote absorption. EMLA is useful for intravenous cannulation in rabbit ears and in young dogs and cats.
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FAQ
Q1: Could i start the order with small quantity ?
A: We accept sample order , the more details please contact us to know about.
Q2: Could you accept customzied order?
A: Yes, we accept customized service according your inquire, you can communicate with sales manager to know more details.
Q3: When the product can be delivery?
A: We normal delivery the product within 2-4 days, the more details will inform to you by our sales manager.
Q4: Could i get certificate of analysis (COA) about product?
A: Of course, please contact us to get it.
Lidocaine Hcl salt, an amide local anesthetic, has anti-inflammatory properties in vitro and in vivo, possibly due to an attenuation of pro-inflammatory cytokines, intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx.Target: Lidocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery. Lidocaine, the first amino amide-type local anesthetic, was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. His colleague Bengt Lundqvist performed the first injection anesthesia experiments on himself.Lidocaine is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide (MEGX) and then subsequently to the inactive glycine xylidide. MEGX has a longer half life than lidocaine but also is a less potent sodium channel blocker. The elimination half-life of lidocaine is approximately 90-120 minutes in most patients. This may be prolonged in patients with hepatic impairment (average 343 minutes) or congestive heart failure (average 136 minutes).
[1]. VAN DER Wal S, et al. Lidocaine increases the anti-inflammatory cytokine IL-10 following mechanical ventilation in healthy mice. Acta Anaesthesiol Scand. 2014 Oct 14. [2]. Acevedo-Arcique CM, et al. Lidocaine, dexmedetomidine and their combination reduce isoflurane minimum alveolar concentration in dogs. PLoS One. 2014 Sep 18;9(9):e106620.
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