A convenient 'NOSE' approach used towards the synthesis ...

30 Sep.,2024

 

A convenient 'NOSE' approach used towards the synthesis ...

A convenient 'NOSE' approach used towards the synthesis of 6-amino-1,3-dimethyl-5-indolyl-1H-pyrimidine-2,4-dione derivatives catalyzed by nano-Ag

V. K. Das, P. Bharali, B. K. Konwar, J. Mikkola, A. Shchukarev and A. J. Thakur, New J. Chem., , 40, DOI: 10./C5NJK

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Antioxidant and Antimicrobial Agent Synthesis 6-Amino-1,3-dimethyluracil is used in the synthesis of various bioactive molecules with antioxidant and antimicrobial properties. A study demonstrated the synthesis of α-Aminophosphonates bearing this compound, which exhibited significant antioxidant activity compared to standard drugs (Nayab et al., ). Additionally, derivatives of this compound have been synthesized and evaluated for their antioxidant and antimicrobial activities, showing promising results (Al-Adhami & Al-Majidi, ).

Molecular Docking and Hydrogen Bonding Studies The compound has been subject to in silico molecular docking studies. These studies support the biological results of compounds synthesized from this compound, especially in understanding their interaction with specific enzymes (Nayab et al., ). Moreover, the hydrogen bonding properties of this compound in crystal structures have been examined, highlighting its potential in crystallography and solid-state chemistry (Ferguson et al., ).

Synthesis of Heterocyclic Compounds this compound serves as a key starting material in the synthesis of various heterocyclic compounds. These include the production of pyrido[2,3-d]pyrimidines, which have potential applications in drug development (Azev et al., ).

Liquid Crystal Research This compound has been used in the synthesis of new mesogens (liquid crystal substances), demonstrating the impact of molecular structure on mesomorphic (liquid crystalline) properties (AbdulKarim-Talaq et al., ).

Green Chemistry Applications Its utilization in green chemistry is notable. For instance, it has been used in water-based, catalyst-free synthesis methods, contributing to more environmentally friendly chemical processes (Das & Thakur, ).

Electrochemical Applications this compound is involved in electrochemical studies, such as its electroreduction behavior, which is important for applications in electrochemical synthesis and electrosorption separation in the caffeine industry (Chen, ).

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