By Dr. Ramon Velazquez Ph.D.
If you are looking for more details, kindly visit bulk supplement citicoline.
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Last updated: Aug 12, 20|
The world's smartest brain supplement.
Learn MoreCholine is one of the most important nutrients for healthy brain function. When it comes to buying choline in a nootropic supplement, there are several forms and options to choose from.
This guide discusses and compares three of the most popular choline sources – Citicoline vs. Alpha-GPC vs. Choline Bitartrate – and then reveals the best choline source to look for in nootropic stack supplements.
You don't want to put just any choline supplement in your head. You want the BEST nootropic choline type for the job.
One of the most frequently asked questions by nootropic supplement newcomers and veterans alike is: Which cholinergic nootropic is the best for my health?
And there's a good reason for the frequency of this question: the cholinergic biopathway is arguably the most important brain pathway for enhancing cognition, due to the brain's high demand of choline. So much so that choline and acetylcholine levels are often viewed as reliable biomarkers of long-term cognitive health.
There are numerous substances and practices that benefit the cholinergic pathway through direct and indirect biomechanisms. For example, Bacopa may help reduce acetylcholine breakdown, and intermittent fasting seems to enhance acetylcholine efficacy.
However, what we're primarily concerned with here is which direct, raw nootropic choline source is the best for cognition in adults?
And most importantly, which nootropic choline form should you look for in the best nootropic supplements?
To answer these questions, let's first learn more about what choline is.
Choline is a vitamin-like macronutrient essential to the functioning of the liver, muscular tissue, and, yes, the brain. Think of choline as one of the basic brain building blocks to cognition itself, given its precursor status to the following compounds:
By improving ACh, PC, and other brain chemicals, raw choline donors benefit cognition by supporting memory and learning, attention and focus, brain energy, brain regeneration, and muscular performance.
However, within the cholinergic biopathway, there are numerous choline analogues, each with a distinct interrelationship with each other:
The diversity of interrelationships in this diagram illustrates the complexity of choosing the right choline supplement, as not all choline types are equal. And according to U.S. statistics, with 90% of the U.S. population estimated to be deficient in choline, it should be apparent why supplementing choline is important for health.
While supplementing a quality, effective cholinergic nootropic is important to maintaining healthy cognitive patterns, establishing a solid diet of choline-rich foods is equally important to ensure there's a cognitive base with which to make cognitive enhancement a possibility.
A deficiency in choline levels often begins with a deficiency in dietary choline consumption.
According to research from the National Institutes of Health, the five foods richest in choline, in terms of milligrams of choline per serving, include:
Adding foods rich in choline to your diet is a smart move to lessen the risk of choline deficiency. However, given the inefficiency of most dietary cholines' abilities to cross the blood-brain barrier, many nootropic users take their choline-rich diets even further with the intake of potent cholinergic nootropics.
Of all the choline-related supplements, the three most popular are choline bitartrate, alpha-GPC, and citicoline.
We'll examine each source in the choline supplement list below, one-by-one, before issuing our final judgment on which nootropic choline source is the best for brain health and cognition. Check it out:
Swap "X-" with the radical C4H5O6, and there you have it: Choline Bitartrate – the simplest, cheapest form of supplementary choline.
Many nootropic supplements opt for choline bitartrate as their source of choline, and in doing so they compromise quality for cost. By weight, this ingredient contains 41% choline, which is a sizable density when compared against other nootropic choline sources.
However, in terms of cognition enhancement, there's a major problem with choline bitartrate supplement: this form of choline is very ineffective at crossing the blood-brain barrier.
Put simply: choline bitartrate does not work.
More specifically, choline bitartrate supplements don't work in human adults.
In rats, however, the influence of dietary choline on free choline levels was found to be significant. One rat study found choline supplementation to promote circulating choline levels by 52% as compared to the choline-free control group – although acetylcholine synthesis was not significantly improved.1 In a separate research study concerning a rat model of brain injury, the supplementation of choline bitartrate was found to improve spatial memory and histological neuronal impairments.2
The healthy, young, human model, on the other hand, demonstrated no acute effects on memory performance and learning following 2 - 2.5 g of choline bitartrate supplementation.3 Again, this is likely due to choline bitartrate's inefficiency at crossing the blood-brain barrier.
As such, choline bitartrate may qualify as a commendable choline form for bodily choline levels but not for nootropic brain performance.
L-alpha glycerylphosphorylcholine (alpha-GPC or α-GPC) nearly matches choline bitartrate in density but has one major significant advantage over standard choline supplements.
That advantage being the ability to cross the blood-brain barrier.
By weight, alpha GPC carries 40% choline, allowing for a potential 40 mg choline per 100 mg alpha-GPC. While sold as a synthesized supplement, alpha-GPC is a naturally occurring compound, found as a natural nutrient in red meats and organs. However, to achieve nootropic effects through this pathway, you'll need to consume a lot of red meat.
And we're certain the non-nootropic side effects of heavy red meat consumption is likely to nullify any potential benefits of its alpha-GPC content.
Alongside the brainy biohackers, athletes and bodybuilders have also taken a liking to alpha-GPC for its sports nutritional benefits, likely due to the cholinergic compound's suggested links with enhanced growth hormone secretion and fat oxidation.6
As a nootropic choline source, alpha-GPC is spot-on. But, believe it or not, there's an even better choline source for nootropic brain enhancement.
Citicoline (or CDP Choline) is more than a choline source. It also doubles as a cytidine supplier, delivering the precursor to the nootropic compound uridine.
While citicoline possesses less choline per serving than alpha-GPC, the combination of choline and cytidine is a potent, powerful tool of cognitive enhancement that exceeds the standard benefits of choline, namely within the realms of brain energy and repair.
Citicoline's diverse biomechanisms qualify the nootropic not only as an acute cognitive enhancer but a long-term brain repair nutrient, granting it a unique status as a universal nootropic compound.
Students, athletes, and gamers may appreciate citicoline's support on attentional and mental performance, whereas, the elderly may appreciate the energized memory support.9
More on Mind Lab Pro® Citicoline
Aside from these raw choline donors, there are other nootropic compounds that benefit the cholinergic pathways through other direct and indirect biomechanisms, most notably:
Strictly in terms of nootropic outcome, which choline supplement source is the best?
If we're going by choline density, choline bitartrate takes the cake. But thankfully this isn't the case as we're primarily measuring the value of these ingredients based on nootropic outcome. Thus, the best nootropic source of choline is citicoline.
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While alpha-GPC provides the densest choline source able to cross the blood-brain barrier, citicoline supplies one of the most effective nootropic combos available on the market: choline and cytidine – essentially providing similar cholinergic benefits as alpha-GPC and then some.
Both choline supplements benefit attention and memory, enhancing ACh activity, yet citicoline holds a tremendous advantage over alpha-GPC with its unique, research-backed, acute and long-term support on brain structure and function.
Any good nootropic supplement must include one of the aforementioned choline sources.
Mind Lab Pro® (the Universal Nootropic™) supplies Citicoline as Cognizin® – the best brand of the best choline source for nootropic supplements.
The quest for the best choline source may end with citicoline, but to get the most out of the supplement, you'll need to stack it with other effective cholinergic compounds, as well as non-cholinergic compounds, to achieve the best mental performance benefits.
As a standalone ingredient, citicoline accomplishes a substantial degree of synergy with its 1-2 combo of choline and cytidine. Mixed with the right ingredients, this foundation nootropic can accomplish even more.
Mind Lab Pro® stacks the best choline source for nootropics in superior Cognizin® form with 10 additional nootropics to unleash 100% Brainpower™.
Introduction
Citicoline, also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.
Citicoline Sodium is the salt form of Citicoline. Citicoline sodium salt is a nontoxic intermediate in the biological synthesis of phosphotidylcholine from choline. Studies indicate that Citicoline sodium salt can increase dopamine receptor densities. In addition, Citicoline sodium salt induces the increases Adrenocorticotropic hormone (ACTH) levels in a Corticotropin-releasing hormone (CRH) independent manner. Other hormones of the hypothalamic–pituitary–adrenal axis are also increased such as LH, FSH, GH and TSH.
Studies conducted on brain cells show that Citicoline sodium salt can reverse the toxic effects caused by hypoxia, ischemia, and trauma. It is suggested that these neuroprotective properties of Citicoline sodium salt may involve reinforcement of intracellular glutathione antioxidative system, attenuation of phospholipase A, activation and prevention of phospholipid degradation, and prevention of glutamate neurotoxicity.
Citicoline Sodium is usually used both in drugs and supplement, especially in Indonesia market, US market, also European market. We can see different brands of drugs and dietary supplement use Citicoline Sodium as a key ingredient.
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Citicoline Sodium is a compound that is essential for human brain health, and is often used to support memory and cognitive function. It is a powerful nutrient that can help to protect the brain from damage caused by aging or other factors, and can also improve mental performance and focus.
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Citicoline Sodium is a natural compound that can enhance cognitive function by increasing acetylcholine levels and supporting the production of phospholipids in the brain. Research has found that Citicoline Sodium can improve memory and attention in healthy adults, especially those experiencing age-related cognitive decline. It has also been shown to increase focus and alertness, making it popular among students and professionals.
In addition to its cognitive benefits, Citicoline Sodium has neuroprotective effects that can help reduce brain damage caused by stroke, traumatic brain injury, and other neurological conditions. It has also been found to aid in the recovery process after a brain injury.
Overall, Citicoline Sodium is a safe and effective supplement that can be easily incorporated into a daily wellness routine. With its ability to improve cognitive function and protect brain health, Citicoline Sodium is a valuable tool for anyone looking to enhance their mental performance and overall well-being.
Citicoline Sodium is a natural compound that has been shown to enhance memory and cognitive function. This supplement works by increasing the levels of acetylcholine in the brain, which is a neurotransmitter that plays a vital role in memory, learning, and attention.
Research has found that Citicoline Sodium supplementation can improve memory in healthy adults, particularly in those experiencing age-related cognitive decline. It has also been shown to enhance working memory, which is crucial for completing complex tasks and decision-making.
Citicoline Sodium has neuroprotective effects that can help to reduce brain damage caused by stroke, traumatic brain injury, and other neurological conditions. This supplement has also been found to aid in the recovery process after a brain injury, which can further improve memory and cognitive function.
Overall, Citicoline Sodium is a safe and effective supplement that can help improve memory and cognitive function. It is a natural compound that has been extensively studied for its benefits, and can be easily incorporated into a daily supplement regimen. With its ability to enhance memory and protect brain health, Citicoline Sodium is a valuable tool for anyone looking to improve their mental performance and overall well-being.
Citicoline Sodium supplementation can improve focus and mental clarity in healthy adults, making it a popular choice for individuals looking to boost their productivity. It has also been shown to enhance cognitive performance during stressful situations, which can help individuals stay focused and alert.
Citicoline Sodium has neuroprotective effects that can help to reduce brain damage caused by stroke, traumatic brain injury, and other neurological conditions. This supplement has also been found to aid in the recovery process after a brain injury, which can further improve mental clarity and cognitive function.
Overall, Citicoline Sodium is a safe and effective supplement that can help enhance mental clarity and cognitive function. It is a natural compound that has been extensively studied for its benefits, and can be easily incorporated into a daily supplement regimen. With its ability to improve focus, mental clarity, and protect brain health, Citicoline Sodium is a valuable tool for anyone looking to improve their mental performance and overall well-being.
Citicoline Sodium is a powerful supplement that can aid in the recovery of traumatic brain injuries. It is a type of choline compound that has been shown to improve cognitive function, enhance memory, and increase focus. Citicoline Sodium works by increasing the production of phosphatidylcholine, a crucial component of brain cell membranes that plays a critical role in brain function and repair.
For those recovering from a traumatic brain injury, Citicoline Sodium can help reduce inflammation, promote healthy brain cell growth, and support overall brain health. It has been shown to improve memory, attention, and cognitive function, making it an excellent choice for those seeking to regain their mental abilities after a brain injury.
Citicoline Sodium is a safe and effective supplement that can be taken orally in capsule or powder form. It is easy to use and has no known side effects. Whether you are recovering from a traumatic brain injury or simply looking to improve your brain health and cognitive function, Citicoline Sodium is an excellent choice that can help you achieve your goals.
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